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. 2021 Apr 29;11:642382. doi: 10.3389/fonc.2021.642382

Table 4.

Collective results for cognitive domain by comparison method using fixed effect model (in bold p < 0.005).

Comparison group/time-point Attention and concentration Depression Executive function Processing speed Verbal memory Visual memory Motor function Language
Baseline Number of studies 8 3 8 5 8 6 5 2
SMD −0.89 0.28 −0.30 0.23 1.46 0.18 0.15 0.85
95% CI lower −0.98 0.06 −0.41 0.04 1.33 0.02 −0.03 0.55
95% CI upper −0.77 0.50 −0.20 0.42 1.60 0.35 0.34 1.14
0.98 0.47 0.97 0.10 0.99 0.91 0.92 0.02
Healthy control Number of studies 4 1 4 3 4 3 1 0
SMD 0.28 0.77 −0.15 −0.38 0.74 −0.05 0.17
95% CI lower 0.16 0.26 −0.27 −0.63 0.61 −0.30 −0.31
95% CI upper 0.40 1.28 -0.03 -0.12 0.86 0.20 0.66
0.92 0.00 0.00 0.95 0.00
No chemotherapy Number of studies 4 2 3 2 4 4 4 3
SMD −0.06 0.36 0.04 0.05 0.04 0.29 0.35 −0.00
95% CI lower −0.28 −0.11 −0.18 −0.25 −0.17 0.07 0.108 −0.28
95% CI upper 0.15 −0.82 0.26 0.35 0.26 0.50 0.60 0.27
0.65 0.00 0.34 0.00 0.62 0.00 0.00 0.53

SMD, standardized mean difference.