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. 2021 Apr 30;8:646786. doi: 10.3389/fmolb.2021.646786

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Copyright © 2021 Xiao, Liu, Yi and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival analysis of LINC02257 and GO term and KEGG pathway analysis in COAD (A) LINC02257 related to the survival time of patients, and with the increase of LINC02257 expression, the prognosis of colon cancer patients was worse. (B) Multivariate COX regression analysis suggests that age and expression of LINC02257 could be independent factors for the prognosis survival of colon cancer patients. (C) GO enrichment analysis shows that the biological processes and molecular functions are strongly associated with LINC02257 in extracellular structure organization, ossification, collagen fibril organization and connective tissue development. (D) KEGG pathway analysis shows five pathways of the significant correlation with LINC02257 expression: PI3K-Akt signaling pathway. Focal adhesion, Phagosome, Regulation of actin cytoskeleton and MAPK signaling pathway (p < 0.05 was considered significant).