Table 3. Leave-one-out sensitivity analyses for adverse events.

	Statistics with study removed
Study name	OR	Lower limit	Upper limit	P-value
Any adverse events
INBUILD	2.35	1.57	3.52	<0.001
INPULSIS-1	2.18	1.49	3.19	<0.001
INPULSIS-2	2.64	1.78	3.92	<0.001
NCT01979952	2.37	1.67	3.34	<0.001
SENSCIS	2.39	1.67	3.41	<0.001
TOMORROW	2.48	1.74	3.53	<0.001
Severe adverse events
INBUILD	1.26	0.96	1.66	0.093
INPULSIS-1	1.02	0.76	1.38	0.885
INPULSIS-2	1.17	0.79	1.73	0.436
SENSCIS	1.04	0.75	1.44	0.809
TOMORROW	1.16	0.82	1.63	0.402
Serious adverse events
INBUILD	1.02	0.83	1.25	0.873
INPULSIS-1	0.95	0.79	1.15	0.615
INPULSIS-2	1.04	0.86	1.27	0.693
NCT01979952	1.01	0.85	1.20	0.911
SENSCIS	0.97	0.80	1.17	0.721
TOMORROW	1.01	0.85	1.21	0.901
Adverse events leading to treatment discontinuation
INBUILD	1.62	1.19	2.21	0.002
INPULSIS-1	1.63	1.21	2.21	0.001
INPULSIS-2	1.95	1.50	2.53	<0.001
SENSCIS	1.67	1.21	2.31	0.002
TOMORROW	1.82	1.37	2.42	<0.001
Fatal adverse events
INBUILD	0.68	0.33	1.37	0.279
INPULSIS-1	0.64	0.32	1.26	0.194
INPULSIS-2	0.62	0.29	1.31	0.211
SENSCIS	0.63	0.36	1.10	0.101
TOMORROW	0.77	0.52	1.15	0.197