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. 2021 May 14;16(5):e0250606. doi: 10.1371/journal.pone.0250606

Fig 1. Elevated IDO activity in HD mouse brains is decreased by ex-vivo iron chelation.

Fig 1

Mouse pups were supplemented with carbonyl iron from postnatal days 10–17 and then were sacrificed at 14 weeks of age. A. Striatal IDO activity is increased in N171-82Q HD mice and significantly decreased by ex vivo iron (III) chelation (50 μM deferoxamine). B. Cortical IDO activity is increased in iron-supplemented HD mice compared to non-supplemented HD mice and activity is decreased by ex vivo iron chelation. C. There is no difference in relative transcript levels of IDO1 in striatum. D. IDO1 mRNA is increased in cortex of HD mice at 14-weeks of age. E, F. Iron increases levels of IDO2 in striatum (E) and cortex (F) but there was no significant effect of HD on IDO2 mRNA. A, B. Bars represent means ± 95% CI. n = 9 wild-type and 11 HD mice in each group. *p<0.05, **p<0.01. C, F. Bars represent means ± SE, n = 6; *p<0.05.