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. Author manuscript; available in PMC: 2021 May 14.
Published in final edited form as: ACS Chem Biol. 2020 Oct 20;15(11):3004–3012. doi: 10.1021/acschembio.0c00662

Figure 5:

Figure 5:

Co-localization of AS-shRNA-lipid derived fluorescence with IBA1 positive cells in the P17 mouse OIR retina. (A-C) Isolectin B4 was used to visualize the retinal vasculatures (green); IBA1 was used to stain the microglial cells (magenta). (D-E) AS-shRNA-lipid derived fluorescence was localized in cells that are also associated with IBA1 positive cells (white arrows), suggesting that IBA1 positive microglia/macrophages (magenta color) could express HIF-1α mRNA that are also associated with neovascularization.41 (F-G) AS-shRNA-lipid derived fluorescence were not observed in ramified IBA1-positive cells (yellow arrows) in the OIR retina.