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. 2021 May 13;60(5):2085–2098. doi: 10.1093/rheumatology/key330

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© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 2 — Illustration of genetic regulation of DNA methylation at the IRF5-TNPO3 pSS susceptibility locus

Data presented here are derived from meQTL analysis by Imgenberg-Kreuz et al. [73]. Top panel: Results (as –log10 P-values) of the pSS case–control EWAS of 100 pSS patients and 400 controls, with cg04864179 being the top differentially methylated CpG site within this locus. Middle panel: Significant meQTLs analysed in 382 controls, genotyped on the ImmunoChip, with the lines connecting the CpG site and corresponding SNPs in darker grey representing a stronger significance of the meQTL. GWAS index SNPs are indicated in red. Bottom panel: The RefSeq genes in the region. meQTL: methylation quantitative trait loci.