Table 1.
Baseline characteristics
| OA patients (n = 164 292) | OA patients without comorbidities1 (n = 99 099) | |
|---|---|---|
| Age, mean (s.d.), years | 66.6 (12.4) | 66.4 (12.3) |
| Age category, n (%) | ||
| 30–39 | 2637 (1.6) | 1730 (1.7) |
| 40–49 | 12007 (7.3) | 7246 (7.3) |
| 50–59 | 32 786 (20.0) | 19 276 (19.5) |
| 60–69 | 48 756 (29.7) | 30 156 (30.4) |
| 70–79 | 40 749 (24.8) | 25 195 (25.4) |
| 80–89 | 23 639 (14.4) | 13 543 (13.7) |
| ≥90 | 3718 (2.3) | 1953 (2.0) |
| Female, n (%) | 107 438 (65.2) | 60 720 (61.3) |
| Joints affected, n (%) | ||
| Spine | 17 243 (10.5) | 10 180 (10.3) |
| Hip | 27 762 (16.9) | 18 075 (18.2) |
| Knee | 45 064 (27.4) | 28 610 (28.9) |
| Other joints | 37 753 (23.0) | 22 189 (22.4) |
| 2 or more joints | 36 470 (22.2) | 20 045 (20.2) |
| Comorbidities | ||
| Diabetes, n (%) | 25 175 (15.3) | 13 608 (13.7) |
| Hypertension, n (%) | 66 866 (40.7) | 38 005 (38.4) |
| Hyperlipidaemia, n (%) | 29 224 (17.8) | 15 497 (15.6) |
| MI/AP, n (%) | 18 868 (11.5) | 9674 (9.8) |
| Stroke/TIA, n (%) | 6352 (3.9) | 3114 (3.1) |
| PAD, n (%) | 6365 (3.9) | 3096 (3.1) |
| UGI/ulcer, n (%) | 5723 (3.5) | 2753 (2.8) |
| Heart failure, n (%) | 6989 (4.3) | 3374 (3.4) |
| Inflammatory arthritis, n (%) | 7949 (4.8) | 4122 (4.2) |
| Fibromyalgia, n (%) | 2492 (1.5) | NA |
| Neuropathic pain disorder, n (%) | 19 202 (11.7) | NA |
| Depression, n (%) | 28 714 (17.5) | NA |
| Anxiety, n (%) | 27 397 (16.7) | NA |
| Psychosis, n (%) | 4084 (2.5) | NA |
| Sleeping disorder, n (%) | 32 278 (19.6) | NA |
| Epilepsy, n (%) | 2404 (1.5) | NA |
| Other MSD during cohort time, n (%) | ||
| Upper extremity | 39 061 (23.8) | 21 702 (21.9) |
| Lower extremity | 61 076 (37.2) | 34 485 (34.8) |
| Back/neck | 51 260 (31.2) | 28 105 (28.4) |
| Other musculoskeletal | 50 559 (30.8) | 27 486 (27.7) |
| None | 57 609 (35.1) | 37 903 (38.2) |
| Renal function, n (%) | ||
| eGFR>60 ml/min | 103 952 (63.3) | 59 613 (60.2) |
| eGFR 30–60 ml/min | 19 382 (11.8) | 10 794 (10.9) |
| eGFR<30 ml/min | 1614 (1.0) | 896 (0.9) |
| Missing | 39 344 (23.9) | 27 796 (28.0) |
MI: myocardial infarction; AP: angina pectoris; TIA: transient ischemic attack; PAD: peripheral arterial disease; UGI: upper gastro-intestinal; MSD: musculoskeletal disorder; eGFR: estimated glomerular filtration rate.