Table 2.

Time trends in prescription rates of antidepressants and anticonvulsants

		Overall trend [AAPC (95% CI)]	Joinpoint (95% CI)	Trend 1	Trend 2
				APC (95% CI)	APC (95% CI)
TOTAL COHORT
Amitriptyline	First	0.4 (−1.5, 2.3)	2014 (2012, 2015)	5.2 (2.3, 8.2)	−8.6 (−13.1, −3.9)
	Episodic	2.6 (0.6, 4.6)	2014 (2012, 2015)	7.6 (4.5, 10.8)	−6.7(−11.2, −2.0)
	Prevalent	3.1 (1.2, 4.9)	2013 (2012, 2015)	7.5 (3.8, 11.4)	−2.2 (−5.0, 0.6)
Nortriptyline	First	5.0 (−1.3, 11.6)
	Episodic	3.7 (−1.2, 8.9)
	Prevalent	2.8 (−0.3, 6.0)
Duloxetine	First	−7.0 (−9.7, −4.1)
	Episodic	−2.4 (−5.1, 0.3)
	Prevalent	3.8 (0.1, 7.7)	2011 (2010, 2012)	−	−0.6 (−2.7, 1.6)
Gabapentin	First	5.9 (2.3, 9.7)
	Episodic	4.1 (1.0, 7.4)
	Prevalent	2.4 (0.9, 3.8)
Pregabalin	First	6.6 (2.9, 10.4)	2012 (2010, 2015)	12.6 (2.4, 23.8)	1.9 (−1.5, 5.5)
	Episodic	8.2 (5.9, 10.5)	2013 (2011, 2014)	12.0 (7.2, 17.0)	3.5 (0.3, 6.8)
	Prevalent	8.8 (7.7, 9.9)	2013 (2012, 2015)	12.7(10.4, 15.0)	4.1 (2.7, 5.6)
WITHOUT COMORBIDITIES
Amitriptyline	First	−1.8 (−5.5, 2.1)
	Episodic	0.8 (−3.8, 5.6)	2013 (2011, 2015)	7.5 (−1.6, 17.5)	−7.1 (−14.2, 0.7)
	Prevalent	1.2 (−1.6, 4.0)	2013 (2012, 2015)	7.3 (1.8, 13.0)	−5.9 (−10.3, −1.3)
Nortriptyline	First	−2.6 (−11.1, 6.6)
	Episodic	−2.2 (−10.5, 6.8)
	Prevalent	−2.4 (−9.6, 5.4)
Duloxetine	First	−12.3 (−17.5, −6.8)
	Episodic	−7.9 (−13.2,−2.4)
	Prevalent	0.2 (−3.5, 4.0)	2011 (2010, 2012)	14.4 (−0.4, 31.3)	−6.3 (−8.7, −3.8)
Gabapentin	First	12.0 (6.6, 17.8)
	Episodic	9.9 (6.2, 13.8)
	Prevalent	4.1 (1.5, 6.9)
Pregabalin	First	4.8 (0.9, 8.8)
	Episodic	6.3 (3.4, 9.2)
	Prevalent	8.9 (5.1, 12.9)	2012 (2011, 2015)	16.5 (5.8, 28.3)	3.2 (−0.2, 6.8)