Table 2. Association between Clinical Variables and Long-Term Survival of Patients with Troponin Elevation and Non-Acute Coronary Syndrome (Group B).
| Survivors (n = 94) |
Non-survivors (n = 59) |
p-value | |
|---|---|---|---|
| Age, median (IQR) | 76(24) years | 84 (13) | <0.001 |
| Male, n(%) | 44 (46.8%) | 29 (49.2%) | 0.77 |
| CV Risk Factors, n(%) | |||
| Diabetes mellitus | 28 (30.8%) | 22 (38.6%) | 0.33 |
| Hypertension | 68 (73.9%) | 44 (78.6%) | 0.52 |
| Previous CAD | 14 (15.2%) | 9 (16.4%) | 0.85 |
| Previous HF | 33 (39.3%) | 31 (56.4%) | 0.049 |
| GFR, mL/(min⋅1.73 m2), median(IQR) | 56 (48) | 45 (34) | 0,05 |
| Heart rate, bpm, median(IQR) | 75 (33) | 84 (36) | 0.10 |
| Previous Medication, n (%) | |||
| Antiplatelets | 22 (23.9%) | 25 (35.5%) | 0.02 |
| Anticoagulants | 34 (37%) | 12 (21.8%) | 0.06 |
| Beta-blockers | 35 (38%) | 18 (32.7%) | 0.52 |
| ACE inhibitors | 57 (62%) | 28 (50.9%) | 0.19 |
| MRA | 9 (20.5%) | 4 (16%) | 0.65 |
| Statins | 36 (39.1%) | 23 (41.8%) | 0.75 |
|
ECG, n (%)
No significant alterations |
51 (64.6%) | 16 (50%) | 0.38 |
| ST elevation | 1 (1.3%) | 0 (0%) | |
| ST-depression or negative T-wave | 16 (20.3%) | 6 (18.8%) | |
| Atrial fibrillation | 28 (35.0%) | 18 (46.2%) | |
| LBBB | 4 (5.1%) | 4 (12.5%) | |
| Pace rhythm | 4 (5.1%) | 3 (9.4%) | |
| Myocardial Necrosis Markers, median (IQR) | |||
| Troponin (ng/mL) at the first evaluation | 0,13 (0,23) | 0,10 (0,18) | 0.61 |
| CK-MB (ng/mL) at the first evaluation | 1,6 (1,8) | 1,9 (2,05) | 0.50 |
| Myoglobin (ng/mL) at the first evaluation | 70 (120) | 99 (175) | 0.06 |
| Isolated troponin elevation at the first evaluation, n (%) | 54 (58.7%) | 22 (40%) | 0.028 |
| Troponin (ng/mL) at the second evaluation, median (IQR) | 0,12(0,16) | 0,14(0,32) | 0,28 |
| % troponin I variation on two sequential measurements, median (IQR) | 0 (32) | 27 (35) | 0.002 |
| Isolated troponin elevation at two sequential measurements, n(%) | 48 (53.9%) | 8 (17.4%) | <0.001 |
| Hospitalization at index event, n(%) | 52 (55.3%) | 51 (86.4%) | <0.001 |
| Coronary revascularization | 0.88 | ||
| No specific therapy, n(%) | 88 (93.6%) | 54 (91.5%) | |
| OMT, n(%) | 5 (5.3%) | 4 (6.8%) | |
| PCI + OMT, n(%) | 1 (1.1%) | 1 (1.1%) |
IQR: interquartile range; CAD: coronary artery disease; HF: heart failure; AIS: acute ischemic stroke; GFR: glomerular filtration rate according to MDRD equation; ACE inhibitor: angiotensin-converting enzyme inhibitor; MRA: mineralocorticoid receptor antagonist; ECG: electrocardiogram; CK: creatine kinase; CK-MB: creatine kinase-MB; OMT: optimized medical therapy; PCI: percutaneous coronary intervention.