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. 2021 May 10;16:3217–3240. doi: 10.2147/IJN.S302450

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© 2021 Zhang et al.

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IGD-Targeted could transport Dox to GD-positive cells and inhibit cell proliferation in acidic environment selectively in vitro. (A) IGD-Targeted could release Dox to GD2⁺ cells in acidic environment. IGD-Targeted was incubated with IMR32 or A431 cells in pH 7.4 or pH 6.5, respectively. Cells were observed under confocal microscope. (B) Cell Viability inhibition ability of IGD-Targeted to GD2⁺ cells. Different concentration of IGD-Targeted was incubated with IMR32 or A431 cells in pH 7.4 or pH 6.5, cell proliferations were detected by MTS assay. (C) Cell Proliferation inhibition of IGD-Targeted to GD2⁺ cells. Different concentration of IGD-Targeted was incubated with IMR32 or A431 cells in pH 7.4 or pH 6.5, cell proliferations were detected by CCK8 assay (*p<0.05, **p<0.01, ***p<0.001).