Fig. 1.

Pathway analysis derived from NAFLD-lipidomics. Pathway (A) and enrichment (B) analyses were performed by integrating the list of query metabolites (mostly lipids) obtained through data mining and retrieved from the Homo sapiens (KEGG) dataset. The following parameters were used for topology analysis (relative-between's-centrality) and Enrichment method (hypergeometric test). The complete list of metabolites used for pathway prediction is shown in Supplemental Table 1. Enrichment analysis: one-tailed P-values are provided after adjusting for multiple testing. FDR, false discovery rate; NAFLD, nonalcoholic fatty liver disease; KEGG, Kyoto Encyclopedia of Genes and Genomes.