Fig. 8.

Targets associated with fatty liver disease: importance & novelty explorer. The plot depicts targets associated with NAFLD with the emphasis on proteins linked to lipid metabolism. Targets are plotted with log-log importance–novelty axes according to the algorithm implemented by the TIN-X resource (56). Briefly, the approach is guided by the following assumptions: the target that is mentioned in many abstracts that also note a specific disease is likely to be of importance to that disease; a target or disease that is mentioned in fewer abstracts is more novel and less well understood; abstracts which mention only a few targets and diseases are more specific and should be given greater weight than those in which many targets and diseases are featured (56). Targets with stronger associations and likely a greater number of publications are located in the upper-left part of the plot. Targets are classified according to the Target Development Level (https://newdrugtargets.org/): Tclin, T, Tchem, Tbio, and Tdark as explained in the figure.NR, nuclear receptor; IDG, Illuminating the Druggable Genome (IDG) Program.