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. 2021 May 14;12:2833. doi: 10.1038/s41467-021-23097-w

Fig. 6. Genetic landscape of CML-CP.

Fig. 6

a Summary of genetic lesions in 148 CP patients. Each column indicates one patient. Clinical annotations including TKI usage for CP treatment, best response to TKI, and progression to BC are also shown. NA not available. b Frequencies of mutations in 148 CP patients. Recurrently mutated or known driver genes are described. Categories of mutations are depicted in different colours, and “multiple” indicates ≥2 distinct mutations found in the same gene in the same patient. c Box plot showing age at CP diagnosis according to the presence of ASXL1 mutations. The median, first, and third quartiles are indicated and whiskers extend to the furthest value within 1.5× the interquartile range. The two-sided Wilcoxon rank-sum test was used to calculate the P value. wt wild type, mut mutated. d Proportion of cases harbouring any genetic abnormalities according to progression to BC. P values were evaluated using the Fisher’s exact test.