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. 2021 May 14;12(5):490. doi: 10.1038/s41419-021-03771-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A CXCR4, MMP2, and MMP9 expression was analyzed in hypoxic-exposed H460 and A549 cells and treated with CPM at various concentrations. B Hypoxia-induced migration in H460 and A549 cells was examined by transwell assay. H460 and A549 cells were cultured in the upper partition of a transwell chamber exposed to 1% O₂, and treated with APEX1 inhibitor E3330, HIF-1α inhibitor LW6 and CPM. Scale bar, 50 μm. C Wound healing assay was performed to test the effect of CPM on cell migration. H460 and A549 cells were incubated with E3330, LW6, and CPM, and exposed to 1% O₂ for 48 h. Scale bar, 100 μm. The results shown were representative of three independent experiments.