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. 2021 May 14;12(5):490. doi: 10.1038/s41419-021-03771-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Xenograft tumor volume was measured in the control group and the CPM-treated group during the 10-day experiment. B Xenografts tumor mass was measured of control and CPM-treated group. C Image of tumors from the control group and the CPM-treated group in a xenograft tumor model. D Analyzing the tumor tissue proliferation, both control and CPM-treated tissue were stained with proliferation marker Ki67. Scale bar, 50 μm. E Xenograft animals body weight was measured in the control group and the CPM-treated group during the 10-day experiment. F Western blot analysis of APEX1 and HIF-1α in control group tumor tissue and CPM-treated tumor of xenograft tumor. G Western blotting analysis of protein expression of CA9, CXCR4, MMP2, and MMP9 in control group tumor tissue and CPM-treated tumor of xenograft tumor. H Immunohistochemical staining of CA9, CXCR4, MMP2, and MMP9 in the section of the control group and the CPM-treated group of xenografts nude mice. I Weight of the vital organs heart, liver, spleen, lung, and kidney of animals of the control group and the CPM-treated group. Data were expressed as mean ± SEM (n = 5). *P < 0.05, compared to control groups.