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. 2021 May 14;12:2830. doi: 10.1038/s41467-021-22752-6

Fig. 3. The CoMET plots depicting genomic regions where the CpGs annotated to AHRR (A) and PHGDH (B) are located.

Fig. 3

The x-axis indicates the position in base pair (bp) (hg19) for the region, while y-axis indicates the strength of association from EWAS with coffee consumption. The red line indicates the Bonferroni threshold for epigenome-wide significance (P = 1.1 × 10−7). The figure was computed using the R-based package CoMET, while the Ensembl is a genome database resource (http://ensemblgenomes.org/). The correlation of the surrounding CpGs was computed using methylation measures in the Rotterdam Study.