Table 3.

Inverse-variance weighted fixed effects meta-analysis of EWAS with tea consumption.

CpG	CHR	Position	Gene	Overall meta-analysis (n = 15,069)
				Β (SE)	P-value	I2	Direction	Het P-v
cg20099906	19	13344820	CACNA1A	−0.0008 (2E−04)	1.06E−06	17.7	-+-+--++--+--+--	0.25
cg05804170	1	3121514	PRDM16	−0.0002 (2E−04)	2.11E−06	0	-+--+-+-+----++-	0.98

The model is adjusted for sex, age, smoking, WBCs, technical covariates, BMI, and alcohol consumption. The epigenome-wide significance threshold for association of DNA methylation sites with tea consumption sets at 1.1 × 10⁻⁷. The table depicts two CpGs suggestively associated with tea consumption with a borderline p-value between 2.0 × 10⁻⁶ and 1.1 × 10⁻⁷.

CpG DNA methylation site, CHR chromosome, Gene annotated gene, β effect estimate, I2 heterogeneity.