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. 2021 May 14;4:574. doi: 10.1038/s42003-021-02015-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — In panel (a) we depict the analysis approach of identifying genes that are highly expressed in similar spatial patterns to the rsfMRI spatial IC maps (i.e., gene expression decoding). Once IC gene lists have been identified, we test these lists for enrichment with known lists of autism-associated functional genomic mechanisms (top left). In panel (b) we show enrichment odds ratios (numbers in each cell) along with the −log10 p value (coloring of the cells) for enrichment tests of specific networks (columns) against known lists of autism-associated genomic mechanisms (rows). Cells outlined with thick black rectangles survive FDR q < 0.05. The column labeled SC > RRB shows the enrichment results when the gene list under consideration comprises genes unique to IC17, but not any of the other ICs. The column labeled SC = RRB shows the enrichment results when the gene list under consideration consists of genes unique to IC03, IC07, and IC13, but not IC12 or IC17. ASD dnPTV, Autism de novo protein-truncating variants; ASD SFARI, SFARI Gene autism-associated genes; ASD DE Downreg, autism differentially expressed downregulated genes; ASD DE Upreg, autism differentially expressed upregulated genes; ASD CTX Downreg CoExpMods, autism downregulated cortical co-expression modules; ASD CTX Upreg CoExpMods, autism upregulated cortical co-expression modules; ASD Excitatory, autism differentially expressed genes in excitatory neurons; ASD Inhibitory, autism differentially expressed genes in inhibitory neurons; ASD Microglia, autism differentially expressed genes in microglia; ASD Oligodendrocyte, autism differentially expressed genes in oligodendrocytes; ASD Astrocyte, autism differentially expressed genes in astrocytes; ASD Endothelial, autism differentially expressed genes in endothelial cells; SCZ DE, schizophrenia differentially expressed genes; BD DE, bipolar disorder differentially expressed genes.

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