Table 2.
Univariate and multivariate analyses of disease-free survival based on HNF1A expression and clinicopathological variables.
| Factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (years) (< 66/≥ 66) | 0.916 | 0.506–1.645 | 0.768 | |||
| Sex (male/female) | 1.192 | 0.663–2.183 | 0.560 | |||
| Histological grade (Others*/Tub1–Tub2) | 1.556 | 0.377–4.273 | 0.487 | |||
| Tumor invasion (T3–4/T2) | 2.563 | 0.791–15.715 | 0.131 | |||
| Lymph node metastasis (N1–2/N0) | 8.051 | 3.486–23.353 | < 0.001 | 6.620 | 2.726–19.837 | < 0.001 |
| Lymphatic invasion (present/absent) | 2.255 | 1.197–4.549 | 0.011 | 1.221 | 0.611–2.623 | 0.583 |
| Vascular invasion (present/absent) | 3.421 | 1.381–11.390 | 0.006 | 2.888 | 1.159–9.647 | 0.020 |
| HNF1A expression (high/low) | 2.154 | 1.167–4.138 | 0.014 | 1.979 | 1.063–3.831 | 0.031 |
*Others: poorly differentiated, mucinous adenocarcinoma, or squamous cell carcinoma.
The significance for the boldunderline indicate independent risk from multivariate analysis.
The significance for the underline indicate significant risk from univaliate analysis.