Table 3.
Univariate and multivariate analyses of overall survival based on HNF1A expression and clinicopathological variables.
| Factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (years) (< 66/≥ 66) | 1.264 | 0.545–3.065 | 0.588 | |||
| Sex (male/female) | 0.790 | 0.338–1.844 | 0.580 | |||
| Histological grade (Others*/Tub1–Tub2) | NA | NA | NA | |||
| Tumor invasion (T3–4/T2) | 2.837 | 0.591–50.906 | 0.231 | |||
| Lymph node metastasis (N1–2/N0) | 5.804 | 1.976–24.711 | < 0.001 | 4.573 | 1.530–19.636 | 0.005 |
| Lymphatic invasion (present/absent) | 1.887 | 0.775–5.263 | 0.185 | |||
| Vascular invasion (present/absent) | 3.425 | 0.998–21.461 | 0.054 | |||
| HNF1A expression (high/low) | 4.437 | 1.626–15.492 | 0.003 | 3.850 | 1.406–13.475 | 0.007 |
*Others: poorly differentiated, mucinous adenocarcinoma, or squamous cell carcinoma.
The significance for the boldunderline indicate independent risk from multivariate analysis.