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. 2021 May 14;12(5):489. doi: 10.1038/s41419-021-03788-4

Fig. 2. Association of higher CXCL10/TLR4 levels in small-for-size graft with tumor recurrence in HCC patients after transplantation.

Fig. 2

Intragraft CXCL10 and TLR4 expressions were examined at hour 2 after liver transplantation. A Enhanced expression of CXCL10 and TLR4 in patients who received small-for-size liver grafts (GWR < 60%) compared to large liver grafts (GWR ≥ 60%) (n = 85). B Higher levels of CXCL10 and TLR4 in the recipients with HCC recurrence than non-recurrent patients (n = 85). C The significant positive correlation between intragraft CXCL10 and TLR4 expression (n = 85). D Co-localization of TLR4 and MDSC (CD33 positive) in liver graft post-transplantation (a representative from three times independent experiments). Scale bars: 5 μm. Error bars indicate standard error of mean; *p < 0.05, **p < 0.01. HCC hepatocellular carcinoma, MDSC myeloid-derived suppressor cell, GWR graft weight ratio.