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. 2021 May 14;12(5):489. doi: 10.1038/s41419-021-03788-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A–C Rat orthotopic liver transplantation model. A More circulatory MDSCs in rats at Day 1, 3, 5 after small-for-size graft transplantation in contrast with whole graft. B Increased intragraft MDSCs (CD11b/c positive) in rats with small-for-size grafts at Day 5. C Increased intragraft mRNA expressions of CXCL10 (Day 3), TLR4 (Day 3, 5), CXCR3 (Day 5) in small-for-size liver graft. D–F Rat orthotopic liver transplantation with tumor recurrence model. D Higher MVD in the tumors from a small-for-size liver graft on Day 14 after transplantation. E Higher expressions of CXCL10 (both in tumor and non-tumor tissue) and TLR4 (in non-tumor tissue) in small-for-size liver graft with tumor recurrence. F More infiltrated MDSCs in small-for-size liver graft with tumor recurrence. N = 5/group; Scale bars: 50 μm; error bars indicate standard error of mean; *p < 0.05, **p < 0.01, ***p < 0.001. MDSC myeloid-derived suppressor cell, MVD microvessel density.