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. 2021 May 14;12(5):489. doi: 10.1038/s41419-021-03788-4

Fig. 5. MDSC mobilization regulated by CXCL10/TLR4 through MMP14 and higher levels of TLR4 on monocytic MDSCs.

Fig. 5

A MMP14, as the most up-regulated gene, in wild type MDSCs with CXCL10 addition compared to those without treatment; MMP14, as the most down-regulated gene, in TLR4−/− MDSCs compared to wild type ones with the same CXCL10 treatment by the screen of mouse motility genes. B More wild type MDSCs transferred to the bottom well in a CXCL10 dosage-dependent manner, while no significantly changed numbers of TLR4−/− MDSCs and MMP14 Ab-blocking wild type MDSCs (30 μg/ml) in the bottom well with/without CXCL10 addition. C Augmentation of TLR4 on monocytic MDSCs in contrast with granulocytic MDSCs in mouse IRH model (N = 6/group). Scale bars: 100 μm. Error bars indicate standard error of mean; *p < 0.05, **p < 0.01, ***p < 0.001. MDSC myeloid-derived suppressor cell, MMP14 matrix metallopeptidase 14, Ab antibody, IRH ischemia/reperfusion plus major hepatectomy, WT wild type.