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. 2021 May 14;12(5):489. doi: 10.1038/s41419-021-03788-4

Fig. 6. Inhibited cancer recurrence with reduced monocytic MDSCs and MMP14 in CXCL10−/− or TLR4−/− mice of IRH with tumor recurrence model.

Fig. 6

A Inhibited tumor development by knockout of CXCL10 or TLR4; scale bars: 500 μm. B No significant change of infiltrated CD31 positive cells in tumor tissue between wild type and CXCR3−/− mice; Scale bars: 50 μm. C Less circulatory and hepatic monocytic MDSCs in CXCL10−/− or TLR4−/− mice. D Significant decrease of infiltrated MMP14 in TLR4−/− mice in contrast with wild-type ones; scale bars: 100 μm. N = 5/group; error bars indicate standard error of mean; *p < 0.05, **p < 0.01, ***p < 0.001. MDSC myeloid-derived suppressor cell, MMP14 matrix metallopeptidase 14, IRH ischemia/reperfusion plus major hepatectomy, WT wild type.