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. 2021 May 14;12:2791. doi: 10.1038/s41467-021-23146-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Cleavage at K205 liberates helices α1-α4 allowing dissociation of inter-subunit interactions at the tip of the complex (i), the helices of domains 2 that are C-terminal to the cut site (from α5 onwards), remain in essentially their original position stabilising the central interface of the tetramer. The α4 helices form a central helical bundle while the other helices N-terminal to the cut site (α1-3) are able to unfurl and move down between the propeller domains to form a new helical bundle (ii–v), which interacts with the membrane via the ends of the helical bundle (vi).