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. 2021 May 14;12(5):491. doi: 10.1038/s41419-021-03783-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Dot plots of the top 10 enriched pathways by GSEA from the comparisons of the control vs. Bam>CG6015 RNAi testes. Color scale and dot size represent FDR value and enrichment score, respectively. b Enrichment plot for the EGFR pathway from the comparisons of the control vs. Bam>CG6015 RNAi testes. Enrichment plot showing the distribution of the enrichment score, leading genes, and ranked list metric. c Box plots of EGFR signaling for all identified genes from the comparisons of the control vs. Bam>CG6015 RNAi testes. d Box plots of EGFR signaling for differentially expressed genes from the comparisons of the control vs. Bam>CG6015 RNAi testes. e Expression-interaction network of the EGFR signaling pathway from the comparisons of the control vs. Bam>CG6015 RNAi testes. Blue and red scales represented low and high expression, respectively, while the circle size is proportional to the statistical significance (-logFDR). Green lines represented protein interactions. f Relative mRNA level of representative down-regulated genes in the control, Bam>CG6015 RNAi and Bam>CG6015 RNAi; Δ86/+ testes. g Relative mRNA levels of representative upregulated genes in the control, Bam>CG6015 RNAi and Bam>CG6015 RNAi; Δ86/+ testes. *P < 0.05, **P < 0.01, ***P < 0.001.