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. 2021 May 14;11:10351. doi: 10.1038/s41598-021-89603-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of LPA on YAP activity in DMD-iPSC-CMs. (A) YAP localization was determined in DMD-iPSC-CMs, not treated, and treated with LPA (scale bar 50 µm). (B) N/C ratio in troponin T-positive cells was evaluated at various concentrations of LPA in Con-iPSC-CMs, DMD-iPSC-CMs, and Ed-DMD-iPSC-CMs (n = 3 sessions, mean analyzed troponin T-positive cell number = 569 ± 177, 320 ± 175, and 271 ± 123 cells, respectively, mean ± SD, *P < 0.05, N.S. not significantly different). (C) N/C ratio in troponin T-positive cells was evaluated for not treated, treated with 1 µmol/L LPA, and treated with 1 µmol/L LPA and 10 µmol/L Y-27632 in DMD-iPSC-CMs (n = 3 sessions, mean analyzed troponin T-positive cell number = 563 ± 77, 302 ± 179, and 235 ± 133 cells, respectively, mean ± SD, *P < 0.05, N.S., not significantly different). (D) N/C ratio in troponin T-positive cells was evaluated for treatments with 0.1% DMSO and 10 µmol/L verteporfin in DMD-iPSC-CMs (n = 3 sessions, mean analyzed troponin T-positive cell number = 824 ± 143 and 852 ± 618 cells, respectively, mean ± SD, N.S., not significantly different).