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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: J Pain. 2020 Nov 21;22(5):498–508. doi: 10.1016/j.jpain.2020.11.004

Figure 3. TACAN AS-ODN attenuates LMWH-induced mechanical hyperalgesia.

Figure 3.

Rats were treated intrathecally with TACAN AS- (120 μg/20 μL) or MM- (120 μg/20 μL) ODN, once a day, for three consecutive days. On the fourth day, approximately 24 h after the last intrathecal administration of ODN, when the mechanical nociceptive threshold was significantly elevated from pre-ODN baseline in the TACAN AS-ODN-treated group (t(5) = 2.340; p=0.0664, for the TACAN MM-ODN-treated group and, t(5)=6.379; ##p=0.0014, for the TACAN AS-ODN-treated group, when the mechanical nociceptive threshold is compared before and approximately 24 hours after the third intrathecal injection of ODNs; paired Student’s t-test), LMWH (1 μg/5 μL) was injected intradermally on the dorsum of the hind paw. Mechanical nociceptive threshold was evaluated 5, 10, 15, 20 and 30 min after LMWH. In the group that received TACAN AS-ODN, hyperalgesia induced by LMWH was markedly attenuated 15, 20 and 30 min after LMWH, when compared with the TACAN MM-ODN- treated group (F(6,60)=5.828, **p<0.0085, when the TACAN AS-ODN- is compared with TACAN MM-ODN-treated group before intradermal LMWH; ***p=0.0002 when the TACAN AS-ODN- is compared with TACAN MM-ODN-treated group 15, 20 and 30 min after LMWH; two-way repeated-measures ANOVA followed by Bonferroni’s multiple comparison test). n=6 per group.