Table 2.

WORMS grade longitudinal changes for high and low impact physical activity over 48 months.

Worms Parameters	High impact	P-value
	Adjusted means changes in WORMS over 48 months [95% CI]	High impact vs Other groups
Overall Worms score	4.65 [3.94,5.35]	0.040
Cartilage
Global Sum	2.25 [1.88,2.61]	0.13
Patella	0.44 [0.31,0.56]	0.97
Trochlea	0.37 [0.26,0.48]	0.56
Medial femur	0.48 [0.35,0.60]	0.034
Medial tibia	0.39 [0.27,0.52]	0.006
Lateral femur	0.34 [0.22,0.45]	0.46
Lateral tibia	0.23 [0.13,0.34]	0.058
Meniscus
Global sum	0.91 [0.68,1.15]	0.066

Worms Parameters	Low impact	P-value
	Adjusted means changes in WORMS over 48 months [95% CI]	Low impact vs Other groups
Overall Worms score	3.46 [2.61,4.32]	0.040
Cartilage
Global Sum	1.80 [1.36,2.24]	0.13
Patella	0.43 [0.28,0.58]	0.97
Trochlea	0.32 [0.19,0.43]	0.56
Medial femur	0.26 [0.10,0.41]	0.034
Medial tibia	0.10 [−0.04,0.26]	0.006
Lateral femur	0.27 [0.13,0.40]	0.46
Lateral tibia	0.40 [0.27,0.53]	0.058
Meniscus
Global sum	0.56 [0.27,0.84]	0.066

Data are listed as adjusted means, adjusted for common risk factors of knee OA age, sex, race and baseline BMI, with [95% Confidence Intervals] and calculated as the numerical means for each different type of physical activity. Significant statistical results (p= ≤0.050) are in bold.