Table 5.

WORMS grade longitudinal changes over 48 months for subjects in bicycling group, swimming group, jogging/running group and sport ball group compared to the remainder of the cohort respectively.

Worms Parameters	Bicycling	P-value	Worms Parameters	Swimming	P-value
	Adjusted means changes in WORMS over 48 months [95% CI]	Bicycling vs other groups		Adjusted means changes in WORMS over 48 months [95% CI]	Swimming vs other groups
Overall Worms score	3.75 [2.54,4.96]	0.43	Overall Worms score	3.99 [2.73,5.26]	0.73
Cartilage			Cartilage
Global Sum	2.04 [1.43,2.66]	0.81	Global Sum	1.93 [1.29,2.58]	0.56
Patella	0.50 [0.30,0.71]	0.61	Patella	0.35 [0.13,0.56]	0.30
Trochlea	0.38 [0.19,0.56]	0.67	Trochlea	0.40 [0.21,0.59]	0.53
Medial femur	0.34 [0.12,0.55]	0.50	Medial femur	0.25 [0.02,0.47]	0.14
Medial tibia	0.16 [−0.06,0.38]	0.15	Medial tibia	0.08 [−0.15,0.32]	0.045
Lateral femur	0.30 [0.12,0.47]	0.89	Lateral femur	0.38 [0.20,0.56]	0.25
Lateral tibia	0.37 [0.18,0.56]	0.53	Lateral tibia	0.46 [0.26,0.66]	0.11
Meniscus			Meniscus
Global sum	0.60 [0.19,1.01]	0.38	Global sum	0.75 [0.32,1.18]	0.91
Worms Parameters	Jogging/running	P-value	Worms Parameters	Sport ball	P-value
	Adjusted means changes in WORMS over 48 months [95% CI]	Jogging/running vs other groups		Adjusted means changes in WORMS over 48 months [95% CI]	Sport ball vs other groups
Overall Worms score	4.50 [3.54,5.46]	0.49	Overall Worms score	3.90 [2.60,5.20]	0.62
Cartilage			Cartilage
Global Sum	2.29 [1.81,2.78]	0,40	Global Sum	2.11 [1.45,2.77]	0.99
Patella	0.49 [0.32,0.65]	0.64	Patella	0.54 [0.32,0.77]	0.40
Trochlea	0.38 [0.23,0.52]	0.60	Trochlea	0.26 [0.06,0.46]	0.38
Medial femur	0.49 [0.32,0.67]	0.24	Medial femur	0.36 [0.12,0.59]	0.66
Medial tibia	0.39 [0.21,0.57]	0.32	Medial tibia	0.21 [−0.03,0.46]	0.39
Lateral femur	0.35 [0.20,0.34]	0.33	Lateral femur	0.42 [0.24,0.61]	0.11
Lateral tibia	0.20 [0.05,0.35]	0.11	Lateral tibia	0.30 [0.10,0.51]	0.91
Meniscus			Meniscus
Global sum	0.71 [0.39,1.04]	0.71	Global sum	0.91 [0.46,1.35]	0.52

Data are listed as adjusted means, adjusted for common risk factors of knee OA age, sex, race and baseline BMI, with [95% Confidence Intervals] and calculated as the numerical means for each different type of physical activity. Significant statistical results (p= ≤0.050) are in bold.