Table 1:

Binocular Amblyopia Therapy using Dichoptic Stimuli

Category	Platform	Relevant Studies	Description of activity	Dichoptic technique
Video game	Falling blocks iPad game	Holmes et al.25 Manh et al.26 Gao et al.30	Game where points are scored by moving falling blocks to form complete lines of blocks	Red-green anaglyphic glasses; high-contrast elements seen by the amblyopic eye and reduced-contrast by the fellow eye
	Dig rush iPad game	Kelly et al.27 Holmes et al.28 Holes et al.29	Action adventure game with miners digging for gold
Video viewing	Dichoptic movie	Birch et al.31 Sauvan et al.35	Movies shown on a passive 3D display	Glasses with polarized lenses; a patterned image mask made of irregularly shaped blobs is applied to the images seen by the amblyopic eye (high contrast) and the inverse mask is applied to the images seen by the fellow eye (reduced contrast)
	Dichoptic movie with interactive tasks	Bossi et al.32	Movies shown on a 3D capable computer monitor and interrupted by interactive tasks to measure suppression	Shutter glasses mounted in a customized ski mask; image presented to the non-amblyopic eye blurred
	BinoVision home system	Mezad-Koursh et al.33	Video or movie shown on head-mounted goggles; customizable content	Contrast and brightness levels reduced for the non-amblyopic eye; superimposed moving objects and momentary repetitive bright video frame stimuli shown only to the amblyopic eye
	Luminopia One	Xiao et al.34	Video shown via a smartphone on a head-mounted display; streaming of wide variety of licensed content	Contrast levels reduced for the non-amblyopic eye; dichoptic masks superimposed so that parts of the video are only visible to the amblyopic eye
Virtual reality (VR)	Interactive Binocular Treatment (I-BiT) system37	Waddingham et al.38 Cleary et al.39 Rajavi et al.40 Herbison et al.41	Interactive games and movies on a 3D VR based computer system	Red-green filter or shutter glasses; enriched image presented to the amblyopic eye; for games, key elements only visible to the amblyopic eye
	Diplopia game in Oculus Rift OC DK2	Žiak et al.42	Games played in a 3D setting in a VR head mounted display connected to a computer	Dichoptic setting in which the central part of the picture is shown differently to each eye; images from both eyes needed to successfully play the games