Table 2.
Summary of the conditional regression models for each locus suggestively associated with asthma exacerbations in patients treated with ICS in the discovery phase.
| Meta-analysis (n=2,681) |
Conditional regression model |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Nearest gene(s) | SNP | Chr. a | Position b | E/NE | Freq. c | OR (95% CI) d | p-value | Conditioned on | p-value |
| ZNF648-GLUL | rs71632139 | 1 | 182326506 | C/G | 0.109 | 1.60 (1.31–1.94) | 3.07 × 10−6 | NA | NA |
| LTBP1 | rs11681246 | 2 | 33466620 | G/A | 0.436 | 0.72 (0.63–0.83) | 3.28 × 10−6 | NA | NA |
| CCDC85A-VRK2 | rs113364932 | 2 | 56668971 | A/G | 0.063 | 2.20 (1.61–3.01) | 7.86 × 10−7 | rs113364932 | NA |
| rs72805125 | 2 | 56684554 | T/C | 0.063 | 2.09 (1.53–2.85) | 3.11 × 10−6 | 0.888 | ||
| CNTNAP5 | rs76496334 | 2 | 125427606 | T/C | 0.022 | 2.29 (1.64–3.19) | 9.69 × 10−7 | rs144289311 | 0.491 |
| rs146921813 | 2 | 125432412 | C/G | 0.022 | 2.26 (1.63–3.16) | 1.34 × 10−6 | 0.534 | ||
| rs141194780 | 2 | 125432413 | A/G | 0.022 | 2.26 (1.63–3.16) | 1.34 × 10−6 | 0.534 | ||
| rs144289311 | 2 | 125432440 | A/G | 0.022 | 2.33 (1.67–3.25) | 6.73 × 10−7 | NA | ||
| rs145694710 | 2 | 125434780 | T/C | 0.022 | 2.28 (1.63–3.17) | 1.21 × 10−6 | 0.515 | ||
| rs17011852 | 2 | 125440426 | G/A | 0.022 | 2.32 (1.66–3.24) | 7.27 × 10−7 | NA | ||
| AOX1 | rs2465662 | 2 | 201501145 | C/T | 0.283 | 1.13 (0.77–1.66) | 4.08 × 10−6 e | rs7587871 | 0.847 |
| rs7587871 | 2 | 201505269 | A/C | 0.318 | 1.09 (0.75–1.58) | 3.10 × 10−6 e | NA | ||
| rs7420798 | 2 | 201506713 | G/A | 0.318 | 1.09 (0.75–1.58) | 3.24 × 10−6 e | NA | ||
| rs12988162 | 2 | 201507154 | A/T | 0.318 | 1.08 (0.75–1.57) | 4.14 × 10−6 e | NA | ||
| CACNA2D3-WNT5A | rs67026078 | 3 | 55162698 | C/T | 0.085 | 1.50 (0.93–2.43) | 4.22 × 10−6 e | NA | NA |
| ZNF608-GRAMD3 | rs444610 | 5 | 125315286 | A/T | 0.398 | 1.36 (1.09–1.69) | 3.68 × 10−6 e | NA | NA |
| NOX3-ARID1B | rs2493700 | 6 | 156826363 | G/C | 0.677 | 0.71 (0.62–0.82) | 1.28 × 10−6 | NA | NA |
| SPATA8-ARRDC4 | rs72759231 | 15 | 97550165 | G/A | 0.058 | 1.97 (1.50–2.59) | 1.30 × 10−6 | NA | NA |
| DLGAP1-ZBTB14 | rs28761328 | 18 | 4746271 | A/T | 0.148 | 1.56 (1.29–1.89) | 4.26 × 10−6 | NA | NA |
a
Chromosome;
b
Positions based on GRCh37/hg19 build;
c
Frequency of the effect allele in European populations from the 1,000 Genomes Project phase 3;
d
Odds ratio for the effect alleles (additive model);
e
Random-effect model was applied since heterogeneity was found between European studies.
CI: Confidence Interval; E: Effect allele; NA: not available; NE: Non-effect allele; SNP: single-nucleotide polymorphism.
Independent SNPs of each gene region are in boldface.