Table 3.
Association results for the independent suggestive associations followed up for replication in populations of European descent.
| SNP | Chr.a | Positionb | Nearest gene(s) | E/NE | Discovery phase |
Replication phase |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Meta-analysis (n=2,681) | ALSPAC (n=258) | CAMP (n=175) | BAMSE (n=105) | Meta-analysis (n=538) | ||||||||||
| OR (95% CI)d | p-value | OR (95% CI)d | p-value | OR (95% CI)d | p-value | OR (95% CI)d | p-value | OR (95% CI)d | p-value | |||||
| rs71632139 | 1 | 182326506 | ZNF648-GLUL | C/G | 1.60 (1.31–1.94) |
3.07 × 10−6 | 1.36 (0.76–2.43) |
0.315 | 1.16 (0.60–2.22) |
0.665 | 1.31 (0.48–3.47) |
0.604 | 1.27 (0.85–1.89) |
0.243 |
| rs11681246 | 2 | 33466620 | LTBP1 | G/A | 0.72 (0.63–0.83) |
3.28 × 10−6 | 1.50 (1.00–2.27) |
0.051 | 1.12 (0.69–1.80) |
0.649 | 1.12 (0.59–2.08) |
0.738 | 1.28 (0.97–1.70) |
0.082 |
| rs113364932 | 2 | 56668971 | CCDC85A-VRK2 | A/G | 2.20 (1.61–3.01) |
7.86 × 10−7 | 0.58 (0.14–2.39) |
0.424 | 1.87 (0.69–5.08) |
0.222 | 0.47 (0.11–1.92) |
0.305 | 1.00 (0.49–2.03) |
0.991 |
| rs144289311 | 2 | 125432440 | CNTNAP5 | A/G | 2.33 (1.67–3.25) |
6.73 × 10−7 | 1.71 (0.72–4.07) |
0.234 | 0.51 (0.14–1.88) |
0.314 | 0.88 (0.13–5.41) |
0.892 | 1.14 (0.58–2.23) |
0.703 |
| rs7587871 | 2 | 201505269 | AOX1 | A/C | 1.09 (0.75–1.58) |
3.10 × 10−6 e | 0.70 (0.44–1.10) |
0.117 | 1.40 (0.89–2.19) |
0.146 | 0.98 (0.53–1.78) |
0.949 | 0.99 (0.75–1.32) |
0.942 |
| rs67026078 | 3 | 55162698 | CACNA2D3-WNT5A | C/T | 1.50 (0.93–2.43) |
4.22 × 10−6 e | 2.06 (1.07–3.97) |
0.032 | 1.68 (0.77–3.65) |
0.193 | 1.53 (0.48–4.71) |
0.471 | 1.83 (1.16–2.90) |
0.010 |
| rs444610 | 5 | 125315286 | ZNF608-GRAMD3 | A/T | 1.36 (1.09–1.69) |
3.68 × 10−6 e | 0.76 (0.51–1.15) |
0.189 | 0.83 (0.53–1.29) |
0.409 | 0.79 (0.43–1.43) |
0.455 | 0.79 (0.61–1.04) |
0.091 |
| rs2493700 | 6 | 156826363 | NOX3-ARID1B | G/C | 0.71 (0.62–0.82) |
1.28 × 10−6 | 1.10 (0.68–1.76) |
0.697 | 1.05 (0.67–1.64) |
0.827 | 0.65 (0.35–1.17) |
0.162 | 0.96 (0.72–1.28) |
0.573 |
| rs72759231 | 15 | 97550165 | SPATA8-ARRDC4 | G/A | 1.97 (1.50–2.59) |
1.30 × 10−6 | 0.91 (0.39–2.14) |
0.829 | 0.60 (0.28–1.27) |
0.180 | 0.83 (0.22–3.05) |
0.785 | 0.74 (0.44–1.24) |
0.247 |
| rs28761328 | 18 | 4746271 | DLGAP1-ZBTB14 | A/T | 1.56 (1.29–1.89) |
4.26 × 10−6 | 0.40 (0.19–0.82) |
0.007 | 1.23 (0.65–2.36) |
0.524 | 0.70 (0.28–1.68) |
0.433 | 0.74 (0.48–1.13) |
0.164 |
a
Chromosome;
b
Positions based on GRCh37/hg19 build;
c
Frequency of the effect allele in European populations from the 1,000 Genomes Project phase 3;
d
Odds ratio for the effect alleles (additive model);
e
Random-effect model was applied since heterogeneity was found between European studies.
CI: Confidence Interval; E: Effect allele; NA: not available; NE: Non-effect allele; SNP: single-nucleotide polymorphism.
SNPs with evidence of replication in independent European populations are in boldface.