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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Nature. 2021 Apr 14;593(7858):294–298. doi: 10.1038/s41586-021-03458-7

Figure 3. Cryo-EM structure of the SR synaptic complex.

Figure 3.

a, Front (left) and top (right) views of the cryo-EM composite map (see Methods) of the SR complex. b, Corresponding views of the structural model of the SR complex. c, Close-up view showing the interface between the LigIV DBD (ribbon) and Ku70 vWA (surface) domains. Regions of the LigIV DBD domain involved in the interaction are depicted. d, Close-up view showing the interface between the XLF CC (ribbon) and the two Ku70 vWA (surface) domains. Spheres depict the locations of missense or truncation mutation residues from cancer patients2 that occur at the interface, although D176X and D178X truncations are also expected to impact XLF-Ku80 interaction due to the lack of XLF C-terminal KBM27,28.