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. Author manuscript; available in PMC: 2022 May 13.
Published in final edited form as: Cell. 2021 Apr 28;184(10):2779–2792.e18. doi: 10.1016/j.cell.2021.03.043

Figure 5. PsychLight accurately predicts hallucinogenic potentials of previously untested compounds.

Figure 5.

A. Structures of 5-halo-DMT derivatives and AAZ-A-154. Colored circles indicate the relative size of the halogen atom compared to each other. B. Both 5-F-DMT and 5-Cl-DMT produce positive ligand scores and induce head-twitches in mice. In contract, 5-Br-DMT produces a negative ligand score and does not induce a HTR (n = 4 mice). C. All 5-halo-DMTs produce dose-dependent decreases in locomotion (n= 4 mice). D. Schild regression analysis reveals that AAZ-A-154 is a psychLight competitive antagonist (n = 3 replicates from 1 passage of cells). E. AAZ-A-154 does not trigger a HTR at any dose compared to that triggered by 5-MeO-DMT (n= 4 mice). F. AAZ-A-154 only decreases locomotion at a very high dose (100 mg/kg) (n = 4 mice). Data are represented as mean ± SEM. ****p<0.0001, ***p<0.001, and *p<0.05, vs. the vehicle control, one-way ANOVA with Dunnett’s test. See also Supplementary Fig. 6E.