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Pharmacokinetic properties and dosing for the direct oral factor Xa inhibitors
| Rivaroxaban | Apixaban | Betrixaban | Edoxaban | |
|---|---|---|---|---|
| Bioavailability | > 80% | > 50% | ~ 35% | > 80% |
| Onset of action, hrs | 2–4 | ~ 3 | 1–3 | 1–2 |
| Half-life, hrs | 5–13 | 9–14 | ~ 20 | 8–10 |
| Metabolism | 1/3 renal; 2/3 liver (CYP 450) | Multiple pathways (25% renal) | Via bile (~ 5% renal) | Multiple (majority renal) |
| Likehood of drug interactions | Low–Mod | Low | Low | Low-Mod |
| Dosing | Oral once daily | Oral twice daily | Oral once daily | Oral once daily |
