Table 2.
Selected demographic, clinical, and cognitive measures
See https://markvcid.partners.org/consortium-protocols-resources for full information.
| Category | Uniform Data Set 3.0, National Alzheimer’s Coordinating Center (UDS3, NACC) elements | MarkVCID added measures |
|---|---|---|
| Demographics & related elements | Year of birth, sex, race and ethnicity, primary language, handedness, marital status, living situation, level of independence, zip code of primary residence, education | Age at registration, self-reported fluency in English, occupational status |
| Medical/Neurological/Psychiatric history | History of cigarette smoking, cardiovascular disease, cerebrovascular disease history, neurologic conditions, medical conditions, substance abuse, psychiatric conditions, medical history | Nature and timing of cerebrovascular disease history |
| Family history | Acquired cognitive impairment/dementia/Alzheimer’s Disease | Stroke/Transient ischemic attack (TIA) |
| General physical measures | Vital signs, additional physical observations (vision and hearing) | Short Physical Performance Battery (SPPB) |
| Neurological exam | Parkinsonian features, cerebrovascular features, other findings | |
| Cognitive diagnosis | Syndromic Diagnosis, primary Etiological Diagnoses, related Etiological Diagnoses | |
| Montreal Cognitive Assessment (MoCA) | Language of test administration, visuospatial/executive, language naming, memory, attention, language repetition and fluency, abstraction, delayed recall, orientation | |
| Neuropsychological Testing Battery | Language of test administration, craft story 21 recall, number span forward and back, Category fluency (animals) verbal fluency [words with F (English) or P (Spanish)], trail making test A and B, Multilingual Naming Test (MINT) | Word list learning (choice of Hopkins Verbal Learning test [HVLT] [46], California Verbal Learning Test-2 [CVLT-2] [47], Spanish English Verbal Learning Test [SEVLT] [48]) |
| Overall Function | Clinical Dementia Rating (CDR) | |
| Depression | Geriatric Depression Scale (GDS) | |
| Laboratory Tests (required) | - | HbA1c; serum, HDL, LDL cholesterol (fasting); triglycerides; creatinine |
| Laboratory Tests (optional) | - | HS-CRP, blood sugar (fasting), homocysteine (fasting), genetics |