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. 2021 Apr 22;22(9):4369. doi: 10.3390/ijms22094369

Figure 2.

Figure 2

Signaling pathways activated by TSLP. TSLP specifically binds to TSLPR expressed by target cells. The TSLP/TSLPR binary aggregate thus recruits IL-7Rα, thereby promoting the assembly of the ternary molecular complex TSLP/TSLPR/IL-7Rα. The latter triggers the activation of intracellular signaling cascades initiated by JAK1/JAK2, which phosphorylates STAT3/5 and also involves NF-κB, PI3K, and MAPK. As a consequence, this transduction network activates target genes encoding pro-inflammatory cytokines (IL-4, IL-5, IL-9, and IL-13) implicated in airway inflammation. TSLP: thymic stromal lymphopoietin; TSLPR: thymic stromal lymphopoietin receptor; IL-7Rα: α subunit of the interleukin-7 receptor; JAK: Janus kinases; STAT: signal transducers and activators of transcription; NF-κB: nuclear factor-κB; PI3K: phosphoinositide 3 kinase; MAPK: mitogen-activated protein kinases. This original figure was created by the authors using BioRender.com.