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Mutations of the inwardly rectifying potassium channel Kir4.1 reported in this study. (A) Topology diagram of Kir 4.1 including the location of the sites of the three mutations. (B) Three-dimensional homology model of human Kir 4.1 homotetramer generated through Swiss- Model protein structure homology-modelling server (http://swissmodel.expasy.org). Molecular visualization was performed by PyMol software.
