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. 2021 Apr 22;13(9):2011. doi: 10.3390/cancers13092011

Figure 1.

Figure 1

Schematic description of the metastatic dissemination model of prostate cancer. The metastatic formation rate (cp) depends on the volume of the primary tumor (Vp(t)). From the settled metastases (Vmi,i(t)), new metastases can be formed at a metastatic formation rate cmi. The blue arrows illustrate the dissemination of metastases from the primary tumor, while the green arrows illustrate dissemination from the metastases. The orange doubled arrow illustrates that tumor cells can be disseminated in any direction into already-established metastases [17].

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