Table 1.
Demographic, Drinking, and Liver Indicators of Study Participants by Group
| Variables | HCs (n = 19) | ALD | P Value* | |||
|---|---|---|---|---|---|---|
| Nonsevere ALD (n = 21) | Severe AH (n = 25) | Total Patients (n = 46) | ||||
| AUD (n = 8) | Moderate AH (n = 13) | |||||
| Age (years) | 36 (24‐60) | 51 (39‐67) | 50 (34‐65) | 47 (27‐66) | 49 (27‐67) | ‐ |
| Total bilirubin (mg/dL) | 0.7 (0.4‐1.3) | 1.5 (0.8‐2.6) | 4.2 (1.2‐18.2) | 12.9 (3.7‐34.2) | 6.7 (0.8‐34.2) | <0.001 |
| Male (female) | 13 (6) | 4 (4) | 7 (6) | 20 (5) | 31 (15) | ‐ |
| INR | N/A | 1.2 (1.1‐1.7) | 1.5 (1.2‐2.8) | 2.0 (1.0‐3.2) | 1.7 (1.0‐3.2) | ‐ |
| AST (U/L) | 27 (19‐66) | 59 (21‐120) | 119 (53‐347) | 88 (16‐190) | 90 (16‐347) | <0.001 |
| ALT (U/L) | 25 (16‐109) | 36.8 (14.0‐60.0) | 48 (18‐194) | 35 (16‐66) | 39 (14‐194) | 0.015 |
| Alkaline phosphatase (IU/L) | 52 (37‐62) | 124 (89‐232) | 173 (80‐518) | 144 (71‐336) | 148 (71‐518) | <0.001 |
| Albumin (g/dL) | 4.2 (3.8‐4.3) | 3.9 (2.6‐4.9) | 2.8 (1.9‐4.5) | 2.4 (1.4‐4.3) | 2.7 (1.4‐4.9) | <0.001 |
| Creatinine (mg/dL) | 0.88 (0.69‐1.07) | 0.69 (0.36‐1.40) | 0.68 (0.32‐1.30) | 0.89 (0.39‐5.68) | 0.79 (0.32‐5.68) | 0.082 |
| MELD score | N/A | 9.2 (6.0‐11.0) | 16 (12‐19) | 24 (20‐39) | 18 (6‐39) | ‐ |
| AUDIT | 2 (1‐5) | 18 (9‐36) | 21 (11‐32) | 22 (10‐39) | 21 (9‐39) | <0.001 |
| MDF | N/A | N/A | 20.42 (3.24‐82.86) | 48.41 (17.52‐121.68) | 34.14 (−8.80 to 121.68) | ‐ |
Values are presented as mean with ranges.
*
Mann‐Whitney U test between HCs and patients abusing alcohol.
Abbreviations: INR, international normalized ratio; N/A, not available.