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The pro-metastatic function and signaling pathways driven by CD151/laminin-binding (LB) integrin complexes and their crosstalk with oncogenic receptor tyrosine kinases (RTKs) in cancer cells and endothelial cells. The role of CD151 illustrated in a gain-of-function manner is based on observations from a series of studies with gene-targeted or shRNA knockdown effect in mouse models or cancer cell lines.
