Figure 2.

Emerging evidence on the context-dependent crosstalk between tetraspanin CD151 and the Wnt signaling pathway in breast cancer. (A) Hypothetical molecular basis for the cooperative role of CD151/laminin-binding integrin complexes and the Wnt/ pathway in basal cell-origin breast cancer. (B) A working model for CD151-mediated suppression of the Wnt/β-catenin signaling, and associated changes in transcription factors Snail and Slug, cell-cell adhesion and EMT in luminal epithelial cell-origin breast cancer.