Figure 2.

Swimmer plot depicting progression-free (dark orange) and overall survival (light orange) from treatment initiation in the first 6 patients enrolled prior to trial amendment and progression-free (dark blue) and overall survival (light blue) in the 10 patients enrolled after the trial amendment. Intervals on and off study therapy are depicted with square brackets ([…]). Black arrow: alive; black cross: death; Dab: addition of low-dose dabrafenib in the first six patients; PR: partial response; red X: dose reduction trametinib; red +: dose reduction dabrafenib; SD: stable disease.