Figure 1.

The co-expression of Δ(90) β-catenin, YAP^S127A and L30P/R34P induces HBs with widespread cyst formation and necrosis. Low power (5×) images of H&E stained tumor HBs. The (left panel) shows the typical crowded fetal-like appearance associated with the co-expression of Δ(90) β-catenin and YAP^S127A [20,30,35]. The (right panel) shows a tumor generated by the combined over-expression of Δ(90) β-catenin + YAP^S127A + R34P. Note the cysts and adjacent regions of widespread necrosis (asterisk). See [48] for additional, higher-power H&E-stained images of the crowded fetal morphology (Reprinted with permission from ref. [48]. Copyright 2021 Children’s Hospital of Pittsburgh of UPMC).