Table 3.

Baseline and postoperative 3mm and 6mm higher order aberrations in cases of high myopia treated with SMILE, femto-LASIK, and PRK

Index	Pupil diameter	Surgical method	Pre-operative	3 M follow-up	12 M follow-up	One-year change	P-value
Total coma (µm)	6-mm	SMILE	0.20 ± 0.09	0.52 ± 0.27	0.56 ± 0.28	0.36 ± 0.28a	0.535b 0.289c
		Femto-LASIK	0.21 ± 0.09	0.50 ± 0.22	0.54 ± 0.22	0.33 ± 0.19a
		PRK	0.21 ± 0.10	0.48 ± 0.24	0.52 ± 0.26	0.31 ± 0.24a
	3-mm	SMILE	0.09 ± 0.06	0.14 ± 0.11	0.16 ± 0.12	0.05 ± 0.11a	0.233b 0.823c
		Femto-LASIK	0.10 ± 0.07	0.16 ± 0.06	0.16 ± 0.09	0.06 ± 0.08a
		PRK	0.09 ± 0.05	0.13 ± 0.08	0.14 ± 0.10	0.05 ± 0.10a
Total SA (µm)	6-mm	SMILE	0.21 ± 0.07	0.46 ± 0.15	0.45 ± 0.15	0.24 ± 0.14a	0.006b < 0.001c
		Femto-LASIK	0.23 ± 0.05	0.56 ± 0.12	0.53 ± 0.12	0.30 ± 0.13a
		PRK	0.22 ± 0.06	0.61 ± 0.21	0.60 ± 0.21	0.38 ± 0.21a
	3-mm	SMILE	0.06 ± 0.03	0.06 ± 0.03	0.08 ± 0.04	0.02 ± 0.04	0.106b 0.722c
		Femto-LASIK	0.06 ± 0.03	0.08 ± 0.04	0.07 ± 0.03	0.01 ± 0.04
		PRK	0.07 ± 0.03	0.06 ± 0.05	0.07 ± 0.04	-0.00 ± 0.06
Total trefoil (µm)	6-mm	SMILE	0.14 ± 0.07	0.16 ± 0.08	0.17 ± 0.08	0.03 ± 0.09	0.426b 0.130c
		Femto-LASIK	0.17 ± 0.10	0.22 ± 0.15	0.21 ± 0.16	0.04 ± 0.16
		PRK	0.13 ± 0.08	0.19 ± 0.11	0.18 ± 0.10	0.05 ± 0.12a
	3-mm	SMILE	0.13 ± 0.09	0.21 ± 0.12	0.23 ± 0.10	0.10 ± 0.15a	< 0.001b 0.006c
		Femto-LASIK	0.15 ± 0.09	0.16 ± 0.11	0.18 ± 0.13	0.03 ± 0.14
		PRK	0.13 ± 0.09	0.16 ± 0.09	0.15 ± 0.11	0.02 ± 0.14

^a Within sub-group statistically significant change

^b Comparison of one-year change in indices between SMILE and femto-LASIK

^c Comparison of one-year change in indices between SMILEand PRK

M months, SA spherical aberration, PRK photorefractive keratectomy, SMILE small incision lenticule extraction, femto-LASIK femtosecond-assisted laser in-situ keratomileusis