Table 6.
Comparison analysis of upstream regulators predicted activated or inhibited based on z-score values (−2 ≤ z-score ≥ 2).
| Upstream Regulator | Molecule Type | z-Score Control | z-Score Odor | p-Value | Target Molecules Control Group |
|---|---|---|---|---|---|
| methylprednisolone | chemical drug | 1.784 | 2.646 | 1.1 × 10−9 | GSTP1,HSPA1A/HSPA1B,IGHG1,IGHG2,IGHM,IGKC,IGKV1-5,IGLC2,IGLC3,PIGR,SERPINB1 |
| lipopolysaccharide | chemical drug | −3.217 | −1.124 | 5.25 × 10−9 | ALB,AZGP1,C3,GSTP1,HSPA1A/HSPA1B,HSPA8,IGHG1,IGHM,IGKC,JCHAIN,LDHA,MDH1,PIGR,S100A9,SERPINB1,TF |
| TNF | cytokine | −1.61 | −0.656 | 1.26 × 10−6 | ACTB,ALB,ARHGDIB,C3,GSTP1,HSPA1A/HSPA1B,HSPA8,IGKC,LDHA,PIGR,S100A9,SERPINB1,TF |
| IL4 | cytokine | −2.214 | N/A | 1.11 × 10−5 | ACTB,ACTG1,C3,HSPA1A/HSPA1B,IGHG1,IGHG2,JCHAIN,PIGR,S100A9 |
| β-estradiol | chemical endogenous | −1.937 | −1.406 | 3.66 × 10−5 | ACTB,ALB,C3,CST2,CST4,GSTP1,HSPA8,LDHA,PIGR,S100A9,TF,YWHAZ |
| KDM1A | enzyme | 2 | N/A | 0.000244 | ARHGDIB,AZGP1,LCP1,SERPINB1 |
| PRDM1 | transcription regulator | −1.98 | N/A | 0.00056 | IGHG1,IGHM,JCHAIN,S100A9 |
| IL1B | cytokine | −2.363 | N/A | 0.00281 | C3,HSPA1A/HSPA1B,LCP1,LDHA,PIGR,S100A9 |
| CSF2 | cytokine | −1.955 | N/A | 0.00765 | C3,LCP1,LDHA,TF |
| EGF | growth factor | −1.964 | N/A | 0.00826 | GSTP1,LDHA,S100A9,TF |
TNF, Tumor necrosis factor; IL4, interleukin 4; KDM1A, Lysine-specific histone demethylase 1A; IL1B, interleukin 1β; CSF2, Granulocyte-macrophage colony-stimulating factor; EGF, epidermal growth factor; GSTP1, glutathione S-transferase P; HSPA1A/HSPA1B, Heat shock 70 kDa protein1A/1B; IGHG1/IGHG2, Immunoglobulin (Ig) γ-1, 2 chain C region; IGHM, Ig µ chain C region; IGKC, Ig κ chain C region; IGKV1-5, Ig κ chain V-I region EU, HK102 (Fragment); IGLC2/IGLC3, Ig λchain C regions iso 2, 3; PIGR, Polymeric immunoglobulin receptor; SERPINB1, Leukocyte elastase inhibitor; ALB, serum albumin; AZGP1, Zinc-alpha-2-glycoprotein; C3, Complement C3c a-chain fragment; JCHAIN, Immunoglobulin J chain; LDHA, L-lactate dehydrogenase A chain; MDH1, Malate dehydrogenase; S100A9, Calgranulin B; TF, Serotransferrin; ACTB/ACTG1, Actin cytoplasmic Iso 1,2; ARHGDIB, Rho GDP-dissociation inhibitor 2; HSPA8, Heat shock cognate 71 kDa protein; CST2, Cystatin SA; CST4, Cystatin S; YWHAZ, 14-3-3 protein ζ/δ; LCP1, Plastin-2.