Vitamin B6 biosynthesis in higher plants. (a) Chemical structure of phosphorylated B6 vitamers. (b) Vitamin B6 de novo biosynthesis and salvage pathways. Both pathways are present in the cytosol. Because it is unclear whether they are also active in the chloroplasts, we did not assign a specific cellular localization for either pathway. Either RiB or RuP, as well as GAP or DAP, can be used. phosphate; RuP, ribulose 5′-phosphate; RiP, ribose 5′-phosphate; DXP, deoxyxylulose 5′-phosphate; Gln, glutamine; PL, pyridoxal; PLP, pyridoxal 5′-phosphate; PM, pyridoxamine; PMP, pyridoxamine 5′-phosphate; PN, pyridoxine; PNP, pyridoxine 5′-phosphate; PDXK, pyridoxine kinase; PDXH, pyridoxine dehydrogenase.