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. 2021 Apr 23;13(9):2033. doi: 10.3390/cancers13092033

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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E2F7 or −8 overexpression promotes spontaneous lung tumorigenesis. (A) Experimental scheme of the long-term induction of E2F7 and −8 in the transgenic mice. (B) Kaplan–Meier overall survival of males and females control (n = 24); E2f7 Tg (n = 21); E2f8 Tg (n = 20); E2f8DBD^mut Tg (n = 22) mice. (C) Microscopic lung tumor incidence in the indicated genotypes of mice euthanized at the end of life-span. Control (n = 16); E2f7 Tg (n = 12); E2f8 Tg (n = 13); E2f8DBD^mut Tg (n = 16) mice. (D) Pathological analysis of the lung tumors. (E) Representative images of the different pathological diagnoses in (E) Data information: In (B) Log-rank Mantel–Cox test. In (C,D) n.s not significant, * p < 0.05 (chi-square).