Figure 5.

Atorvastatin prevents endothelial cell loss and vasa vasorum proliferation after global ischemia. Treatment with atorvastatin for 1-week after GCI decreased endothelial cell loss and restrained vasa vasorum proliferation (A). The 4-week atorvastatin treatment after GCI considerably reduced endothelial cell loss and significantly inhibited vasa vasorum proliferation (C). Scatter dot plot bar graphs showing the quantification of endothelial cells and vWF levels at 1 and 4 weeks (B,D, respectively). Data are mean ± S.E.M.; for both acute and chronic model, n = 3–5 for each sham group, n = 6–8 for each ischemia group. * Significantly different from the vehicle-treated group, * p < 0.05.